tag:blogger.com,1999:blog-11971193715900408352024-03-14T01:03:21.367-07:00Scientist-Doctor: The new approach to personalized medicine and personalized sciencegoal-oriented highly-personalized research projects for interdisciplinary teamsYana Aznaurovahttp://www.blogger.com/profile/00763932592404857719noreply@blogger.comBlogger15125tag:blogger.com,1999:blog-1197119371590040835.post-13611422400361624862014-09-01T12:22:00.002-07:002014-09-01T12:26:54.369-07:00StartUp Village, Skolkovo<div dir="ltr" style="text-align: left;" trbidi="on">
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<span style="font-family: 'Times New Roman'; font-size: small; font-weight: 400; letter-spacing: normal; text-align: left; text-transform: none;"><b>StartUp Village</b> - </span><span lang="EN-US" style="background-attachment: initial; background-clip: initial; background-image: initial; background-origin: initial; background-position: initial; background-repeat: initial; background-size: initial; font-size: 12pt; line-height: 115%;">second annual startup
conference for innovators and entrepreneurs, which is held in Skolkovo (an
innovative "</span><span lang="EN-US" style="font-size: 12pt; line-height: 115%;">scientific city" </span><span lang="EN-US" style="background-attachment: initial; background-clip: initial; background-image: initial; background-origin: initial; background-position: initial; background-repeat: initial; background-size: initial; color: #252525; font-size: 12pt; line-height: 115%;">The site aims to be a
highly modern complex created to encourage science and technology companies. </span><br />
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Yana Aznaurovahttp://www.blogger.com/profile/00763932592404857719noreply@blogger.com0tag:blogger.com,1999:blog-1197119371590040835.post-64310590634019499602014-06-29T08:17:00.002-07:002014-06-29T12:07:44.113-07:00International Symposium on Geroprotectors<div dir="ltr" style="text-align: left;" trbidi="on">
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<span style="background-color: transparent; color: #555555; font-family: Arial, Helvetica, sans-serif; line-height: 20px; text-align: justify;">The aging process remains one of the biggest challenges in the biological sciences. Since the advent of recorded human history, we know that countless generations have sought to develop medicines to control it’s outcome.</span><span style="background-color: transparent; color: #555555; font-family: Arial, Helvetica, sans-serif; line-height: 20px; text-align: justify;"> </span></div>
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<span style="font-family: Arial, Helvetica, sans-serif;">Aging lies at the core of every age-related disease and affects every person on the planet. It represents an unbearable toll on the economies of the developed countries resulting in over two trillion dollars in direct medical costs, costs of caring and lost productivity in the US and EU alone. Yet, pharmaceutical companies fail to see the practical applications of aging research as many early experiments with drugs that held promise in slowing the aging processes resulted in commercial failures and write offs. </span></div>
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<span style="font-family: Arial, Helvetica, sans-serif;">Lack of business models, regulation and absence of a clear set of aging biomarkers make it difficult for large pharmaceutical companies to fully engage in aging research. Unlike other events that are geared towards academia or have a broad range of topics, this forum intends to focus on drug discovery and pharmaceuticals that may have a role in postponing the aging processes, preventing the age-related diseases and evaluating the effectiveness of various small molecules with geroprotective properties.</span></div>
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The event will showcase the research projects in aging research to the leaders of the pharmaceutical industry. The symposium will comprise into the three sessions relevant to the drug discovery companies. Each session will be chaired by the top expert in the field:</div>
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<strong>Session I: </strong>Predicting the activity of geroprotective drugs: in-silico screening, omics data analysis and rational drug design</div>
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<strong><strong>Session II: </strong>Drugs with the potential geroprotective properties</strong></div>
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<strong>Session III: </strong>Aging Biomarkers: how do we measure aging and geroprotective efficacy?</div>
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<strong>Session IV:</strong> Trends in Aging Research and Drug DiscoveryThe forum is part of <a href="http://www.miptec.ch/" style="color: #5288cb; text-decoration: none;">MipTek 2014</a>, the largest drug discovery conference in Europe attracting over 3,000 delegates from the pharmaceutical industry.</div>
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The forum is organized by:Alex Zhavoronkov, PhD (<a href="http://www.bg-rf.org.uk/" style="color: #5288cb; text-decoration: none;">The Biogerontology Research Foundation, UK</a>)<br />
and Bhupinder Bullar, PhD (<a href="http://www.novartis.com/" style="color: #5288cb; text-decoration: none;">Novartis Pharma AG, Switzerland</a>)</div>
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Yana Aznaurovahttp://www.blogger.com/profile/00763932592404857719noreply@blogger.com0tag:blogger.com,1999:blog-1197119371590040835.post-32398799608963241922014-06-27T15:12:00.002-07:002014-09-01T12:27:23.250-07:0012 WCE in Brazil - Photo post<div dir="ltr" style="text-align: left;" trbidi="on">
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<span style="background-color: white; font-family: Arial, Tahoma, Verdana, sans-serif; font-size: 13px; line-height: 18.200000762939453px;">Our abstract<b> "</b></span><span style="background-color: white; font-family: Arial, Tahoma, Verdana, sans-serif; font-size: 13px; line-height: 18.200000762939453px;"><b>Bioinformatic analysis of signaling pathways involved in the development of endometriosis</b></span><span style="background-color: white; font-family: Arial, Tahoma, Verdana, sans-serif; font-size: 13px; line-height: 18.200000762939453px;"><b>' </b>'</span><span style="background-color: white; font-family: Arial, Tahoma, Verdana, sans-serif; font-size: 13px; line-height: 18.200000762939453px;">has been accepted for poster presentation in the section on Pathogenesis / aetiology for the entire duration of <b>World Congress on Endometriosis WCE2014</b>.</span><br />
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WCE was held in the WTC Complex - the most comprehensive business complex in Latin America, bringing together in one place the best services in hospitality, events, decoration and business.</div>
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Few words about WCE. It is the first attendee-centered meeting on endometriosis. The first World Congress on Endometriosis was organised in 1986 in Clermont-Ferrand.<br />
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WCE 2014 provided a unique opportunity of concentrating into a four days the updated knowledge, the biological findings, and the global research perspectives on an enigmatic chronic condition affecting millions of young women and adversely impacting on fertility and health-related quality of life.<br />
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Opening Ceremony<br />
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<span style="font-size: x-small;">With WES President Linda Giudice</span></div>
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<span style="font-size: x-small;"> Famous Octavio Frias de Oliveira bridge in Sao Paolo</span><br />
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<img alt="WES President Linda Giudice, SBE President Rui Ferriani, WCE2014 President Mauricio Abrao, WES President Elect Neil Johnson and WCE2017 President Catherine Allaire at the Closing Ceremony of the 12th World Congress on Endometriosis" src="http://endometriosis.ca/wp-content/uploads/WCE-team.png" /><br />
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<span style="font-size: x-small;">WES President Linda Giudice, SBE President Rui Ferriani, WCE2014 President Mauricio Abrao, WES President Elect Neil Johnson and WCE2017 President Catherine Allaire at the Closing Ceremony of the 12th World Congress on Endometriosis. http://endometriosis.ca/news/article/highlights-from-12th-world-congress-on-endometriosis-wce2014/</span><br />
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<span lang="EN-US" style="text-align: left;"><b>Endometriosis Awareness Month</b> (in some countries </span><span lang="EN-US" style="border: 1pt none windowtext; padding: 0cm; text-align: left;">it is just for one week (<u>3 -9 March
2014</u>) - </span><span lang="EN-US" style="background-color: white; background-position: initial initial; background-repeat: initial initial; text-align: left;">is a worldwide initiative to raise awareness of this common, chronic and
enigmatic gynecological disease, which </span><span lang="EN-US" style="text-align: left;">affects approximately 176
million women of reproductive age.</span></div>
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<span lang="EN-US">Endometriosis
can present with severe symptoms such as chronic pelvic pain, pain with
menstruation, pain during intercourse (dyspareunia) and dysmenorrhea. However,
in the majority of cases endometriosis is asymptomatic in early stages. <o:p></o:p></span></div>
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<span lang="EN-US">Endometriosis
causes infertility in up to 30% of women who suffer from this disease and</span><span lang="EN-US"> it carries a huge personal and social cost.<o:p></o:p></span></div>
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<span lang="EN-US"><b>Endometriosis Week/Month</b> <b>aims to</b> create a greater
awareness and understanding of endometriosis and to show inspiring examples of
living with this disease. Women with endometriosis from all over the world come
together to support each other.<o:p></o:p></span></div>
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<span lang="EN-US"><i>Don’t hesitate to visit your gynecologist in case even minor
pelvic pain. Women must be more attentive to their health and not to put their
career on the forefront. </i><o:p></o:p></span></div>
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Yana Aznaurovahttp://www.blogger.com/profile/00763932592404857719noreply@blogger.com0tag:blogger.com,1999:blog-1197119371590040835.post-80770621838343271532013-11-27T11:14:00.001-08:002013-11-29T03:19:52.104-08:00Women in science<div class="separator" style="clear: both;"><p class="MsoNormal"><span lang="EN-US" style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">It never was a secret that the number of men in science is larger than the number of women. This may have some historical roots; in some case the tendency comes from people’s attitude. However, the situation is being changed in the course of time and now science is becoming more attractive for women.</span></p><span style="font-family: helvetica; font-size: 15px; -webkit-tap-highlight-color: rgba(26, 26, 26, 0.296875); -webkit-composition-fill-color: rgba(175, 192, 227, 0.230469); -webkit-composition-frame-color: rgba(77, 128, 180, 0.230469); "></span></div><div class="separator" style="clear: both;"><br></div><div class="separator" style="clear: both;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">In 2002 Charles Hirshberg published an article "My mother, the scientist" about <b><i>Joan Feynman</i></b>, </span></div><div class="panel-pane pane-entity-field pane-node-field-headline dek"><h2 style="padding-bottom: 2px; margin: 0px; "><span style="font-size: 17px; -webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">a outstanding</span><span style="font-size: 17px; -webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0); "> astro</span><span style="background-color: rgba(255, 255, 255, 0); font-size: 17px; -webkit-text-size-adjust: auto; ">physicist and the sister of one of the most famous scientists of the 20th century (Richard Feynman).</span></h2></div><div class="separator" style="clear: both;"><span style="background-color: rgba(255, 255, 255, 0); -webkit-text-size-adjust: auto; "><br></span></div><div class="separator" style="clear: both;"><span style="background-color: rgba(255, 255, 255, 0); -webkit-text-size-adjust: auto; ">When 8-year-old Joan announced that she intended to be a scientist, her mother explained that it was impossible. <u>"Women can't do science," she said, "because their brains can't understand enough of it." </u></span></div><div class="separator" style="clear: both;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);"><br><i>"It wasn't until her 14th birthday-March 31, 1942-that her notion of becoming a scientist was revived. Richard presented her with a book called Astronomy. "It was a college textbook. I'd start reading it, get stuck, and then start over again. This went on for months, but I kept at it. When I reached page 407, I came across a graph that changed my life." My mother shuts her eyes and recites from memory: "'Relative strengths of the Mg+ absorption line at 4,481 angstroms . . . from Stellar Atmospheres by Cecilia Payne.' Cecilia Payne!" </i></span></div><div class="separator" style="clear: both;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);"><br><div class="separator" style="clear: both;"><a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEidhzwZLcj3qKZtJKTdopVVjgi4IWwMZBvDmlTEP44rmhbsAxObfZeK959Te4h6R-5ZQb4-0nD7LapmuXR7KlHlwG39TFvDSNxk0lnm_4nKKG3pGkkZfSnc277lSJgijsLlo4YbiZraFKrW/s640/blogger-image--181790991.jpg" imageanchor="1" style="margin-left: 1em; margin-right: 1em;"><img border="0" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEidhzwZLcj3qKZtJKTdopVVjgi4IWwMZBvDmlTEP44rmhbsAxObfZeK959Te4h6R-5ZQb4-0nD7LapmuXR7KlHlwG39TFvDSNxk0lnm_4nKKG3pGkkZfSnc277lSJgijsLlo4YbiZraFKrW/s640/blogger-image--181790991.jpg"></a></div><div class="separator" style="clear: both;"><span style="font-family: '.HelveticaNeueUI'; font-size: 15px; line-height: 19px; white-space: nowrap; -webkit-tap-highlight-color: rgba(26, 26, 26, 0.296875); -webkit-composition-fill-color: rgba(175, 192, 227, 0.230469); -webkit-composition-frame-color: rgba(77, 128, 180, 0.230469); -webkit-text-size-adjust: none; ">http://www.popsci.com/scitech/article/2002-04/my-mother-scientist</span></div><div class="separator" style="clear: both;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);"><br></span></div><div class="separator" style="clear: both;">What's it like to have a mother-scientist? <i><span style="background-color: rgba(255, 255, 255, 0); ">"I asked what a scientist <my mother> was, and she handed me a spoon. "Drop it on the table," she said. I let it fall to the floor. "Why did it fall?" she asked. "Why didn't it float up to the ceiling?" It had never occurred to me that there was a "why" involved. "Because of gravity," she said. "A spoon will always fall, a hot-air balloon will always rise." I dropped the spoon again and again until she made me stop. I had no idea what gravity was, but </span><b>the idea of "Why?"</b><span style="background-color: rgba(255, 255, 255, 0); "> kept rattling around in my head."</span></i></div><div class="separator" style="clear: both;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);"><br></span></div>This article, full of love and pride of mother, shows </span><span style="background-color: rgba(255, 255, 255, 0); -webkit-text-size-adjust: auto; ">how exceptional and unusual was the profession - scientist - among women. </span></div><div class="separator" style="clear: both;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);"><br></span></div><div class="separator" style="clear: both;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">At present, the number of women in science is growing, but not all people know about most of them.</span></div><div class="separator" style="clear: both;"><br></div><div class="separator" style="clear: both;"><a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEhqMFA6gySwvGY4OJ2TpNsmBgeEfEfEBJORPWedVuRUIFsuKQYuoNbqhX-CXwAmBP7IYxtwJQIRn1jJtECUhg6wWN1iUL_jjnMDOBT2YWoARB5ClkhTeq4XC47rGs4qga5B1E6Ks2hj7gXu/s640/blogger-image--745276483.jpg" imageanchor="1" style="margin-left: 1em; margin-right: 1em;"><img border="0" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEhqMFA6gySwvGY4OJ2TpNsmBgeEfEfEBJORPWedVuRUIFsuKQYuoNbqhX-CXwAmBP7IYxtwJQIRn1jJtECUhg6wWN1iUL_jjnMDOBT2YWoARB5ClkhTeq4XC47rGs4qga5B1E6Ks2hj7gXu/s640/blogger-image--745276483.jpg"></a></div><div class="separator" style="clear: both;"><br></div><div class="separator" style="clear: both;">There are at about 45 Nobel Prize winners among women:</div><div class="separator" style="clear: both;"><br></div><div class="separator" style="clear: both;"><div class="by_year" style="box-sizing: border-box; margin: 0px; padding: 0px; direction: ltr; "><p style="box-sizing: border-box; margin: 5px 0px; padding: 0px; direction: ltr; "><a href="http://www.nobelprize.org/nobel_prizes/medicine/laureates/2009/" style="box-sizing: border-box; outline: 0px; -webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0); "><font color="#000000"><b><i>The Nobel Prize in Physiology or Medicine 2009</i></b></font></a></p><h6 style="box-sizing: border-box; margin: 0px 0px 5px; padding: 0px; direction: ltr; text-rendering: optimizelegibility; "><a class="text_link" href="http://www.nobelprize.org/nobel_prizes/medicine/laureates/2009/blackburn-facts.html" style="box-sizing: border-box; outline: 0px; padding-left: 11px; background-image: url(http://www.nobelprize.org/images/icons/menu-arrow-fold.png); font-size: 17px; -webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0); background-position: 0px 5px; background-repeat: no-repeat no-repeat; "><font color="#000000"><i>Elizabeth H. Blackburn</i></font></a></h6><p style="box-sizing: border-box; margin: 0px 0px 1.45em; padding: 0px; direction: ltr; "><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">"for the discovery of how chromosomes are protected by telomeres and the enzyme telomerase"</span></p><p style="box-sizing: border-box; margin: 5px 0px; padding: 0px; direction: ltr; "><a href="http://www.nobelprize.org/nobel_prizes/medicine/laureates/2009/" style="box-sizing: border-box; outline: 0px; -webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0); "><font color="#000000"><i><b>The Nobel Prize in Physiology or Medicine 2009</b></i></font></a></p><h6 style="box-sizing: border-box; margin: 0px 0px 5px; padding: 0px; direction: ltr; text-rendering: optimizelegibility; "><a class="text_link" href="http://www.nobelprize.org/nobel_prizes/medicine/laureates/2009/greider-facts.html" style="box-sizing: border-box; outline: 0px; padding-left: 11px; background-image: url(http://www.nobelprize.org/images/icons/menu-arrow-fold.png); font-size: 17px; -webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0); background-position: 0px 5px; background-repeat: no-repeat no-repeat; "><font color="#000000"><i>Carol W. Greider</i></font></a></h6><p style="box-sizing: border-box; margin: 0px 0px 1.45em; padding: 0px; direction: ltr; "><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">"for the discovery of how chromosomes are protected by telomeres and the enzyme telomerase"</span></p><p style="box-sizing: border-box; margin: 5px 0px; padding: 0px; direction: ltr; "><a href="http://www.nobelprize.org/nobel_prizes/medicine/laureates/2008/" style="box-sizing: border-box; font-weight: bold; outline: 0px; -webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0); "><font color="#000000"><i>The Nobel Prize in Physiology or Medicine 2008</i></font></a></p><h6 style="box-sizing: border-box; margin: 0px 0px 5px; padding: 0px; direction: ltr; text-rendering: optimizelegibility; "><a class="text_link" href="http://www.nobelprize.org/nobel_prizes/medicine/laureates/2008/barre-sinoussi-facts.html" style="box-sizing: border-box; outline: 0px; padding-left: 11px; background-image: url(http://www.nobelprize.org/images/icons/menu-arrow-fold.png); font-size: 17px; -webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0); background-position: 0px 5px; background-repeat: no-repeat no-repeat; "><font color="#000000"><i>Françoise Barré-Sinoussi</i></font></a></h6><p style="box-sizing: border-box; margin: 0px 0px 1.45em; padding: 0px; direction: ltr; "><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">"for their discovery of human immunodeficiency virus"</span></p><p style="box-sizing: border-box; margin: 5px 0px; padding: 0px; direction: ltr; "><a href="http://www.nobelprize.org/nobel_prizes/medicine/laureates/2004/" style="box-sizing: border-box; outline: 0px; -webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0); "><font color="#000000"><b><i>The Nobel Prize in Physiology or Medicine 2004</i></b></font></a></p><h6 style="box-sizing: border-box; margin: 0px 0px 5px; padding: 0px; direction: ltr; text-rendering: optimizelegibility; "><a class="text_link" href="http://www.nobelprize.org/nobel_prizes/medicine/laureates/2004/buck-facts.html" style="box-sizing: border-box; outline: 0px; padding-left: 11px; background-image: url(http://www.nobelprize.org/images/icons/menu-arrow-fold.png); font-size: 17px; -webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0); background-position: 0px 5px; background-repeat: no-repeat no-repeat; "><font color="#000000"><i>Linda B. Buck</i></font></a></h6><p style="box-sizing: border-box; margin: 0px 0px 1.45em; padding: 0px; direction: ltr; "><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">"for their discoveries of odorant receptors and the organization of the olfactory system"</span></p><p style="box-sizing: border-box; margin: 5px 0px; padding: 0px; direction: ltr; "><a href="http://www.nobelprize.org/nobel_prizes/medicine/laureates/1995/" style="box-sizing: border-box; outline: 0px; -webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0); "><font color="#000000"><b><i>The Nobel Prize in Physiology or Medicine 1995</i></b></font></a></p><h6 style="box-sizing: border-box; margin: 0px 0px 5px; padding: 0px; direction: ltr; text-rendering: optimizelegibility; "><a class="text_link" href="http://www.nobelprize.org/nobel_prizes/medicine/laureates/1995/nusslein-volhard-facts.html" style="box-sizing: border-box; outline: 0px; padding-left: 11px; background-image: url(http://www.nobelprize.org/images/icons/menu-arrow-fold.png); font-size: 17px; -webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0); background-position: 0px 5px; background-repeat: no-repeat no-repeat; "><font color="#000000"><i>Christiane Nüsslein-Volhard</i></font></a></h6><p style="box-sizing: border-box; margin: 0px 0px 1.45em; padding: 0px; direction: ltr; "><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">"for their discoveries concerning the genetic control of early embryonic development"</span></p><p style="box-sizing: border-box; margin: 5px 0px; padding: 0px; direction: ltr; "><a href="http://www.nobelprize.org/nobel_prizes/medicine/laureates/1988/" style="box-sizing: border-box; font-weight: bold; outline: 0px; -webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0); "><font color="#000000"><i>The Nobel Prize in Physiology or Medicine 1988</i></font></a></p><h6 style="box-sizing: border-box; margin: 0px 0px 5px; padding: 0px; direction: ltr; text-rendering: optimizelegibility; "><a class="text_link" href="http://www.nobelprize.org/nobel_prizes/medicine/laureates/1988/elion-facts.html" style="box-sizing: border-box; outline: 0px; padding-left: 11px; background-image: url(http://www.nobelprize.org/images/icons/menu-arrow-fold.png); font-size: 17px; -webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0); background-position: 0px 5px; background-repeat: no-repeat no-repeat; "><font color="#000000"><i>Gertrude B. Elion</i></font></a></h6><p style="box-sizing: border-box; margin: 0px 0px 1.45em; padding: 0px; direction: ltr; "><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">"for their discoveries of important principles for drug treatment"</span></p><p style="box-sizing: border-box; margin: 5px 0px; padding: 0px; direction: ltr; "><a href="http://www.nobelprize.org/nobel_prizes/medicine/laureates/1986/" style="box-sizing: border-box; outline: 0px; -webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0); "><font color="#000000"><b><i>The Nobel Prize in Physiology or Medicine 1986</i></b></font></a></p><h6 style="box-sizing: border-box; margin: 0px 0px 5px; padding: 0px; direction: ltr; text-rendering: optimizelegibility; "><a class="text_link" href="http://www.nobelprize.org/nobel_prizes/medicine/laureates/1986/levi-montalcini-facts.html" style="box-sizing: border-box; outline: 0px; padding-left: 11px; background-image: url(http://www.nobelprize.org/images/icons/menu-arrow-fold.png); font-size: 17px; -webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0); background-position: 0px 5px; background-repeat: no-repeat no-repeat; "><font color="#000000"><i>Rita Levi-Montalcini</i></font></a></h6><p style="box-sizing: border-box; margin: 0px 0px 1.45em; padding: 0px; direction: ltr; "><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">"for their discoveries of growth factors"</span></p><p style="box-sizing: border-box; margin: 5px 0px; padding: 0px; direction: ltr; "><a href="http://www.nobelprize.org/nobel_prizes/medicine/laureates/1983/" style="box-sizing: border-box; font-weight: bold; outline: 0px; -webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0); "><font color="#000000"><i>The Nobel Prize in Physiology or Medicine 1983</i></font></a></p><h6 style="box-sizing: border-box; margin: 0px 0px 5px; padding: 0px; direction: ltr; text-rendering: optimizelegibility; "><a class="text_link" href="http://www.nobelprize.org/nobel_prizes/medicine/laureates/1983/mcclintock-facts.html" style="box-sizing: border-box; outline: 0px; padding-left: 11px; background-image: url(http://www.nobelprize.org/images/icons/menu-arrow-fold.png); font-size: 17px; -webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0); background-position: 0px 5px; background-repeat: no-repeat no-repeat; "><font color="#000000"><i>Barbara McClintock</i></font></a></h6><p style="box-sizing: border-box; margin: 0px 0px 1.45em; padding: 0px; direction: ltr; "><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">"for her discovery of mobile genetic elements"</span></p><p style="box-sizing: border-box; margin: 5px 0px; padding: 0px; direction: ltr; "><a href="http://www.nobelprize.org/nobel_prizes/medicine/laureates/1977/" style="box-sizing: border-box; outline: 0px; -webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0); "><font color="#000000"><i><b>The Nobel Prize in Physiology or Medicine 1977</b></i></font></a></p><h6 style="box-sizing: border-box; margin: 0px 0px 5px; padding: 0px; direction: ltr; text-rendering: optimizelegibility; "><a class="text_link" href="http://www.nobelprize.org/nobel_prizes/medicine/laureates/1977/yalow-facts.html" style="box-sizing: border-box; outline: 0px; padding-left: 11px; background-image: url(http://www.nobelprize.org/images/icons/menu-arrow-fold.png); font-size: 17px; -webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0); background-position: 0px 5px; background-repeat: no-repeat no-repeat; "><font color="#000000"><i>Rosalyn Yalow</i></font></a></h6><p style="box-sizing: border-box; margin: 0px 0px 1.45em; padding: 0px; direction: ltr; "><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">"for the development of radioimmunoassays of peptide hormones"</span></p><p style="box-sizing: border-box; margin: 5px 0px; padding: 0px; direction: ltr; "><a href="http://www.nobelprize.org/nobel_prizes/medicine/laureates/1947/" style="box-sizing: border-box; font-weight: bold; outline: 0px; -webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0); "><font color="#000000"><i>The Nobel Prize in Physiology or Medicine 1947</i></font></a></p><h6 style="box-sizing: border-box; margin: 0px 0px 5px; padding: 0px; direction: ltr; text-rendering: optimizelegibility; "><a class="text_link" href="http://www.nobelprize.org/nobel_prizes/medicine/laureates/1947/cori-gt-facts.html" style="box-sizing: border-box; outline: 0px; padding-left: 11px; background-image: url(http://www.nobelprize.org/images/icons/menu-arrow-fold.png); font-size: 17px; -webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0); background-position: 0px 5px; background-repeat: no-repeat no-repeat; "><font color="#000000"><i>Gerty Theresa Cori, née Radnitz</i></font></a></h6><p style="box-sizing: border-box; margin: 0px 0px 1.45em; padding: 0px; direction: ltr; "><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">"for their discovery of the course of the catalytic conversion of glycogen"</span></p></div></div><div class="separator" style="clear: both;"><span style="font-family: '.HelveticaNeueUI'; font-size: 15px; line-height: 19px; white-space: nowrap; -webkit-tap-highlight-color: rgba(26, 26, 26, 0.292969); -webkit-composition-fill-color: rgba(175, 192, 227, 0.230469); -webkit-composition-frame-color: rgba(77, 128, 180, 0.230469); ">(http://www.nobelprize.org/nobel_prizes/lists/women.html) </span></div><div class="separator" style="clear: both;"><span style="font-family: '.HelveticaNeueUI'; font-size: 15px; line-height: 19px; white-space: nowrap; -webkit-tap-highlight-color: rgba(26, 26, 26, 0.292969); -webkit-composition-fill-color: rgba(175, 192, 227, 0.230469); -webkit-composition-frame-color: rgba(77, 128, 180, 0.230469); "><br></span></div><div class="separator" style="clear: both;"><span style="font-family: '.HelveticaNeueUI'; font-size: 15px; line-height: 19px; white-space: nowrap; -webkit-tap-highlight-color: rgba(26, 26, 26, 0.292969); -webkit-composition-fill-color: rgba(175, 192, 227, 0.230469); -webkit-composition-frame-color: rgba(77, 128, 180, 0.230469); "><br></span></div><div class="separator" style="clear: both;"><span style="font-family: '.HelveticaNeueUI'; font-size: 15px; line-height: 19px; white-space: nowrap; -webkit-tap-highlight-color: rgba(26, 26, 26, 0.292969); -webkit-composition-fill-color: rgba(175, 192, 227, 0.230469); -webkit-composition-frame-color: rgba(77, 128, 180, 0.230469); "><div class="separator" style="clear: both;"><a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEgqdlrCiDbuNXzFbGfoZGG3m9Vid3HdzeUihc8DDcDuDHNy9P8lpjHwSyM7fSu6hCCkjqvyzhmrVr0U8IRPgpPdO4f5wZytIXDXikxXRnPdrJreckAvpVj76znsTXpC-7x0WRLuILrvCEt9/s640/blogger-image--2081653953.jpg" imageanchor="1" style="margin-left: 1em; margin-right: 1em;"><img border="0" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEgqdlrCiDbuNXzFbGfoZGG3m9Vid3HdzeUihc8DDcDuDHNy9P8lpjHwSyM7fSu6hCCkjqvyzhmrVr0U8IRPgpPdO4f5wZytIXDXikxXRnPdrJreckAvpVj76znsTXpC-7x0WRLuILrvCEt9/s640/blogger-image--2081653953.jpg"></a></div><div class="separator" style="clear: both;"><span style="-webkit-tap-highlight-color: rgba(26, 26, 26, 0.296875); ">http://womenrockscience.tumblr.com/tagged/Posters</span></div><div class="separator" style="clear: both;"><br></div></span><span style="-webkit-tap-highlight-color: rgba(26, 26, 26, 0.292969); -webkit-composition-fill-color: rgba(175, 192, 227, 0.230469); -webkit-composition-frame-color: rgba(77, 128, 180, 0.230469); -webkit-text-size-adjust: auto; ">Each of </span><i style="-webkit-tap-highlight-color: rgba(26, 26, 26, 0.292969); -webkit-composition-fill-color: rgba(175, 192, 227, 0.230469); -webkit-composition-frame-color: rgba(77, 128, 180, 0.230469); -webkit-text-size-adjust: auto; ">women in science</i><span style="-webkit-tap-highlight-color: rgba(26, 26, 26, 0.292969); -webkit-composition-fill-color: rgba(175, 192, 227, 0.230469); -webkit-composition-frame-color: rgba(77, 128, 180, 0.230469); -webkit-text-size-adjust: auto; "> has made an invaluable contribution to science, and at the same time was a great wife and mother. </span></div><div class="separator" style="clear: both;"><span style="-webkit-tap-highlight-color: rgba(26, 26, 26, 0.292969); -webkit-composition-fill-color: rgba(175, 192, 227, 0.230469); -webkit-composition-frame-color: rgba(77, 128, 180, 0.230469); -webkit-text-size-adjust: auto; "><br></span></div><div class="separator" style="clear: both;"><span style="font-family: '.HelveticaNeueUI'; font-size: 15px; line-height: 19px; white-space: nowrap; -webkit-tap-highlight-color: rgba(26, 26, 26, 0.292969); -webkit-composition-fill-color: rgba(175, 192, 227, 0.230469); -webkit-composition-frame-color: rgba(77, 128, 180, 0.230469); "><br></span></div><div class="separator" style="clear: both;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">It was extraordinary</span><span style="background-color: rgba(255, 255, 255, 0); -webkit-text-size-adjust: auto; "> and even strange in the past centuries. But now women are changing the world through science o</span><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">n an equal footing with men. </span></div>Yana Aznaurovahttp://www.blogger.com/profile/00763932592404857719noreply@blogger.com0tag:blogger.com,1999:blog-1197119371590040835.post-85969677862328746992013-11-12T11:59:00.001-08:002013-11-16T12:35:57.396-08:00Scientific news<div class="separator" style="clear: both;"><div class="separator" style="clear: both;"><div><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);"><b><i>A systematic experimental evaluation of microRNA markers of human bladder cancer.</i></b></span></div><div><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);"><i><u>Zabolotneva A, Zhavoronkov AA, Shegay PV, Gaifullin NM, Alekseev BY, Roumiantsev SA, Garazha AV, Kovalchuk O, Aravin A and Buzdin AA.</u></i></span></div><div><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);"><br></span></div><div><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">Scientists </span><span style="-webkit-tap-highlight-color: rgba(26, 26, 26, 0.292969); -webkit-composition-fill-color: rgba(175, 192, 227, 0.230469); -webkit-composition-frame-color: rgba(77, 128, 180, 0.230469); -webkit-text-size-adjust: auto; ">reported the first comprehensive validated database of miRNA markers of human bladder cancer. </span><span style="background-color: rgba(255, 255, 255, 0); -webkit-text-size-adjust: auto; ">They have conducted genome-wide miRNA profiling in 17 urothelial carcinoma bladder tissues and in nine normal urothelial mucosa samples using three methods: an Illumina HT-12 microarray hybridization (MA) analysis a suppression-subtractive hybridization (SSH) assay followed by deep sequencing (DS) and DS alone. </span><span style="background-color: rgba(255, 255, 255, 0); -webkit-text-size-adjust: auto; ">Based on this data, MA and SSH data appear to be inadequate for studying differential miRNA expression in the bladder.</span></div><div><span style="background-color: rgba(255, 255, 255, 0); -webkit-text-size-adjust: auto; "><br></span></div><div><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">Find out the full text:</span></div><div><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);"><a href="http://www.frontiersin.org/Journal/10.3389/fgene.2013.00247/abstract">http://www.frontiersin.org/Journal/10.3389/fgene.2013.00247/abstract</a></span></div></div><div class="separator" style="clear: both;"><br></div><div class="separator" style="clear: both;"><a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEjz7XBghed4qWHogba0_N7x5qzFKNvceRdlUPNA0Zn-64vkC4dMetbTueTDqWIfEp5X0zPtCt2bSUTNMxq1L1nr4TowvdMZT2o0vv7XqVZGtY9l-xrdyfoNteLdaAVIzopbjwzWN2I3ygSI/s640/blogger-image-1627207608.jpg" imageanchor="1" style="margin-left: 1em; margin-right: 1em;"><img border="0" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEjz7XBghed4qWHogba0_N7x5qzFKNvceRdlUPNA0Zn-64vkC4dMetbTueTDqWIfEp5X0zPtCt2bSUTNMxq1L1nr4TowvdMZT2o0vv7XqVZGtY9l-xrdyfoNteLdaAVIzopbjwzWN2I3ygSI/s640/blogger-image-1627207608.jpg"></a></div><div class="separator" style="clear: both;"><br></div><div style="-webkit-tap-highlight-color: rgba(26, 26, 26, 0.296875); -webkit-composition-fill-color: rgba(175, 192, 227, 0.230469); -webkit-composition-frame-color: rgba(77, 128, 180, 0.230469); "><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0); "><b><i>Human-specific endogenous retroviral insert serves as an enhancer for the schizophrenia-linked gene PRODH</i></b></span></div><div style="-webkit-tap-highlight-color: rgba(26, 26, 26, 0.296875); -webkit-composition-fill-color: rgba(175, 192, 227, 0.230469); -webkit-composition-frame-color: rgba(77, 128, 180, 0.230469); "><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0); "><i><u>Maria Suntsova, Elena V. Gogvadze, Sergey Salozhin, Nurshat Gaifullin, Fedor Eroshkin, Sergey E. Dmitriev, Natalia Martynova, Kirill Kulikov, Galina Malakhova, Gulnur Tukhbatova, Alexey P. Bolshakov, Dmitry Ghilarov, Andrew Garazha, Alexander Aliper, Charles R. Cantor, Yuri Solokhin, Sergey Roumiantsev, Pavel Balaban, Alex Zhavoronkov, Anton Buzdin.</u></i></span></div><div style="-webkit-tap-highlight-color: rgba(26, 26, 26, 0.296875); -webkit-composition-fill-color: rgba(175, 192, 227, 0.230469); -webkit-composition-frame-color: rgba(77, 128, 180, 0.230469); "><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0); "><i><u><br></u></i></span></div><div style="text-align: -webkit-auto; "><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);"><em style="margin: 0px; padding: 0px; border: 0px; outline-style: none; text-align: left; vertical-align: baseline; ">PRODH</em><span style="text-align: left; "> encodes proline dehydrogenase, which is involved in neuromediator synthesis in the CNS.</span></span></div><div style="text-align: -webkit-auto;"><span style="-webkit-tap-highlight-color: rgba(26, 26, 26, 0.296875); -webkit-composition-fill-color: rgba(175, 192, 227, 0.230469); -webkit-composition-frame-color: rgba(77, 128, 180, 0.230469); -webkit-text-size-adjust: auto; text-align: left; ">A human-specific endogenous retroviral insert (hsERV) that acts as an enhancer for human </span><em style="-webkit-tap-highlight-color: rgba(26, 26, 26, 0.296875); -webkit-composition-fill-color: rgba(175, 192, 227, 0.230469); -webkit-composition-frame-color: rgba(77, 128, 180, 0.230469); -webkit-text-size-adjust: auto; margin: 0px; padding: 0px; border: 0px; outline-style: none; text-align: left; vertical-align: baseline; ">PRODH</em><span style="-webkit-tap-highlight-color: rgba(26, 26, 26, 0.296875); -webkit-composition-fill-color: rgba(175, 192, 227, 0.230469); -webkit-composition-frame-color: rgba(77, 128, 180, 0.230469); -webkit-text-size-adjust: auto; text-align: left; ">, hsERV_PRODH, was </span><span style="text-align: left; -webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">identified.</span></div><div style="text-align: -webkit-auto; "><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);"><span style="text-align: left; ">It was shown that the hsERV_PRODH enhancer acts synergistically with the CpG island of </span><em style="margin: 0px; padding: 0px; border: 0px; outline-style: none; text-align: left; vertical-align: baseline; ">PRODH</em><span style="text-align: left; "> and is regulated by methylation. Scientists detected high </span><em style="margin: 0px; padding: 0px; border: 0px; outline-style: none; text-align: left; vertical-align: baseline; ">PRODH</em><span style="text-align: left; "> expression in the hippocampus, which was correlated with the undermethylated state of this enhancer. </span><em style="margin: 0px; padding: 0px; border: 0px; outline-style: none; text-align: left; vertical-align: baseline; ">PRODH </em><span style="text-align: left; ">regulatory elements provide neuron-specific transcription in hippocampal cells, and the mechanism of hsERV_PRODH enhancer activity involves the binding of transcriptional factor SOX2. </span></span></div><div style="-webkit-tap-highlight-color: rgba(26, 26, 26, 0.296875); -webkit-composition-fill-color: rgba(175, 192, 227, 0.230469); -webkit-composition-frame-color: rgba(77, 128, 180, 0.230469); "><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0); "><i><u><br></u></i></span></div><div style="-webkit-tap-highlight-color: rgba(26, 26, 26, 0.296875); -webkit-composition-fill-color: rgba(175, 192, 227, 0.230469); -webkit-composition-frame-color: rgba(77, 128, 180, 0.230469); "><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0); ">The full text you can find here: </span><a href="http://www.pnas.org/content/early/2013/11/07/1318172110.abstract?sid=ed986954-8c96-4f36-bfc9-559bf70099e2" style="-webkit-text-size-adjust: auto; ">http://www.pnas.org/content/early/2013/11/07/1318172110.abstract?sid=ed986954-8c96-4f36-bfc9-559bf70099e2</a><span style="background-color: rgba(255, 255, 255, 0); -webkit-text-size-adjust: auto; "> </span></div><div style="-webkit-tap-highlight-color: rgba(26, 26, 26, 0.296875); -webkit-composition-fill-color: rgba(175, 192, 227, 0.230469); -webkit-composition-frame-color: rgba(77, 128, 180, 0.230469); "><br></div></div><div class="separator" style="clear: both;"><div class="separator" style="clear: both;"><div class="separator" style="clear: both;"><a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEhuGiwIoCn4Kd_Vs3TcgYLSWqruYa3BGJDpp48GrC4znn_P5gDgbsmBo5mnFHyzPe0C-2jn1mdH82IIGHDVj5BsvFmSYU0UUPtAD1qmY7DFXSKs6SHbH-V3ufjvMbTc5lD1o3px2fOptZx_/s640/blogger-image--306856303.jpg" imageanchor="1" style="margin-left: 1em; margin-right: 1em;"><img border="0" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEhuGiwIoCn4Kd_Vs3TcgYLSWqruYa3BGJDpp48GrC4znn_P5gDgbsmBo5mnFHyzPe0C-2jn1mdH82IIGHDVj5BsvFmSYU0UUPtAD1qmY7DFXSKs6SHbH-V3ufjvMbTc5lD1o3px2fOptZx_/s640/blogger-image--306856303.jpg"></a></div><br></div><div class="separator" style="clear: both;"><br></div><h1 itemprop="name" class="art-title" style="text-align: -webkit-auto; margin: 0px 0px 0.5em; padding: 0px; border: 0px; background-position: 0px 50%; "><span style="font-size: 17px; -webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0); "><i>Biomedical Progress Rates as New Parameters for Models of Economic Growth in Developed Countries. </i></span><i style="font-size: 17px; -webkit-text-size-adjust: auto; font-weight: normal;">Alex Zhavoronkov, Maria Litovchenko</i></h1><div class="art-authors" style="text-align: -webkit-auto; margin: 0px 0.5em 0px 0px; vertical-align: bottom; "><span style="background-color: rgba(255, 255, 255, 0); -webkit-text-size-adjust: auto; ">Biomedical progress will likely increase the healthy productive lifespan and the number of years of government support in the old age. In this paper you can find</span><span style="background-color: rgba(255, 255, 255, 0); -webkit-text-size-adjust: auto; "> several new parameters that can be applied to established models of economic growth: the biomedical progress rate, the rate of clinical adoption and the rate of change in retirement age. The biomedical progress rate is comprised of the rejuvenation rate (extending the productive lifespan) and the non-rejuvenating rate (extending the lifespan beyond the age at which the net contribution to the economy becomes negative). While staying within the neoclassical economics framework and extending the overlapping generations (OLG) growth model and assumptions from the life cycle theory of saving behavior, authors provide an example of the relations between these new parameters in the context of demographics, labor, households and the firm.</span></div></div><div class="separator" style="clear: both;"><div><div class="separator" style="clear: both;"><br></div><span style="font-family: '.HelveticaNeueUI'; font-size: 15px; line-height: 19px; white-space: nowrap; -webkit-tap-highlight-color: rgba(26, 26, 26, 0.296875); -webkit-composition-fill-color: rgba(175, 192, 227, 0.230469); -webkit-composition-frame-color: rgba(77, 128, 180, 0.230469); ">Full text: http://www.mdpi.com/1660-4601/10/11/5936</span></div></div>Yana Aznaurovahttp://www.blogger.com/profile/00763932592404857719noreply@blogger.com2tag:blogger.com,1999:blog-1197119371590040835.post-53544942620863924112013-10-01T13:30:00.000-07:002013-10-02T16:25:19.470-07:00Russian scientists in the "Rejuvenation Research"<div dir="ltr" style="text-align: left;" trbidi="on">
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<span lang="EN-US">As you can remember, recently I wrote about Anastasia Shindyapina's talk at the SENS6 conference. In this post I would like to tell you more about her scientific work called </span><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);"><span style="font-weight: bold; text-align: -webkit-auto; "> </span><span style="text-align: -webkit-auto; "><b>"Bioinformatic analysis of factors involved in age-related mineralization of soft tissues"</b>.</span></span></div><div class="MsoNormal" style="text-align: -webkit-auto;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);"><span style="text-align: -webkit-auto; "><br></span></span></div><div class="MsoNormal" style="text-align: -webkit-auto;"><span style="text-align: left; -webkit-tap-highlight-color: rgba(26, 26, 26, 0.296875); -webkit-composition-fill-color: rgba(175, 192, 227, 0.230469); -webkit-composition-frame-color: rgba(77, 128, 180, 0.230469); ">First of all, where you can find out the full version of this article? The results of the study were accepted for publication by a high-impact journal in biogerontology <b>“Rejuvenation Research”</b> and will be published shortly and can be cited as <u>“Mineralization of the connective tissue: a complex molecular process leading to age-related loss of function”, Anastasia Shindyapina, Garik V Mkrtchyan, Tatiana Gneteeva, Sveatoslav Buiucli, M Kulka, B Tancowny, Alexander Aliper, Alexander Zhavoronkov</u>, Rejuvenation Research, ahead of print. doi:10.1089/rej.2013.1475, </span><a href="http://online.liebertpub.com/doi/abs/10.1089/rej.2013.1475" style="text-align: left; -webkit-tap-highlight-color: rgba(26, 26, 26, 0.296875); -webkit-composition-fill-color: rgba(175, 192, 227, 0.230469); -webkit-composition-frame-color: rgba(77, 128, 180, 0.230469); "><span style="color: windowtext; text-decoration: none; ">http://online.liebertpub.com/doi/abs/10.1089/rej.2013.1475</span></a><span style="text-align: left; -webkit-tap-highlight-color: rgba(26, 26, 26, 0.296875); -webkit-composition-fill-color: rgba(175, 192, 227, 0.230469); -webkit-composition-frame-color: rgba(77, 128, 180, 0.230469); "> , PMID </span><a href="tel:23902273" x-apple-data-detectors="true" x-apple-data-detectors-type="telephone" x-apple-data-detectors-result="1" style="text-align: left; -webkit-tap-highlight-color: rgba(26, 26, 26, 0.296875); -webkit-composition-fill-color: rgba(175, 192, 227, 0.230469); -webkit-composition-frame-color: rgba(77, 128, 180, 0.230469); ">23902273</a></div><div class="MsoNormal" style="text-align: -webkit-auto;"><br></div><div class="MsoNormal" style="text-align: -webkit-auto;"><div class="separator" style="clear: both;"><a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEi1KvE-PtjZhOwhaIg6h6X4gb8Fir2ZReru_1UbfPB5sLDm-ODJA8L_Tzt_GA53cFPsQaRw2uPzkMZV7eVZTRsSohO47fUYLEnJd4MUQC3_e8fh3P6kU3hMSyeQba4hW8AAIUa9krgZhpvu/s640/blogger-image-1616254384.jpg" imageanchor="1" style="margin-left: 1em; margin-right: 1em;"><img border="0" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEi1KvE-PtjZhOwhaIg6h6X4gb8Fir2ZReru_1UbfPB5sLDm-ODJA8L_Tzt_GA53cFPsQaRw2uPzkMZV7eVZTRsSohO47fUYLEnJd4MUQC3_e8fh3P6kU3hMSyeQba4hW8AAIUa9krgZhpvu/s640/blogger-image-1616254384.jpg"></a></div><div class="separator" style="clear: both;"><br></div><div class="separator" style="clear: both;"><span style="text-align: left; -webkit-tap-highlight-color: rgba(26, 26, 26, 0.296875); -webkit-composition-fill-color: rgba(175, 192, 227, 0.230469); -webkit-composition-frame-color: rgba(77, 128, 180, 0.230469); ">“Aging inevitably leads to the loss of function on many levels. Mineralization of the connective tissue is one of the causes and consequences of aging and is a complex multifactorial process. Metabolic activity, diseases and external stress factors may cause calcification, but most importantly, it occurs spontaneously. Our goal is to identify least toxic ways to both prevent calcification and to repair the accumulated</span><span style="text-align: left; -webkit-tap-highlight-color: rgba(26, 26, 26, 0.296875); -webkit-composition-fill-color: rgba(175, 192, 227, 0.230469); -webkit-composition-frame-color: rgba(77, 128, 180, 0.230469); "> </span><span style="text-align: left; -webkit-tap-highlight-color: rgba(26, 26, 26, 0.296875); -webkit-composition-fill-color: rgba(175, 192, 227, 0.230469); -webkit-composition-frame-color: rgba(77, 128, 180, 0.230469); ">aggregates.”, said </span><i style="text-align: left; -webkit-tap-highlight-color: rgba(26, 26, 26, 0.296875); -webkit-composition-fill-color: rgba(175, 192, 227, 0.230469); -webkit-composition-frame-color: rgba(77, 128, 180, 0.230469); "><b>Anastasia Shindyapina, ASUS Fellow for Bioinformatics and Medical Information Technology, PhD-candidate at the Moscow State University and researcher at FOIRMYS.</b></i></div><br></div><div class="MsoNormal" style="text-align: -webkit-auto;"><br></div><div class="MsoNormal" style="text-align: -webkit-auto;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);"><span style="text-align: -webkit-auto; "><div class="separator" style="clear: both;"><a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEhEwW7vuvnCTpQ5qK58zhdu4dbSC0fR9l2HQu_FezXa4HwFcAiXNMjTUa_g_kpGuVMi_Uxc8ST_Sy905HktC-l5dM6QvHs4wlM-bI7_uf092RZMDh37Ei-n-UL5XjifDQTpQl-S873_6IKV/s640/blogger-image--1546081378.jpg" imageanchor="1" style="margin-left: 1em; margin-right: 1em;"><img border="0" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEhEwW7vuvnCTpQ5qK58zhdu4dbSC0fR9l2HQu_FezXa4HwFcAiXNMjTUa_g_kpGuVMi_Uxc8ST_Sy905HktC-l5dM6QvHs4wlM-bI7_uf092RZMDh37Ei-n-UL5XjifDQTpQl-S873_6IKV/s640/blogger-image--1546081378.jpg"></a></div><br></span></span></div><div class="MsoNormal" style="text-align: -webkit-auto;"><span style="text-align: left; -webkit-tap-highlight-color: rgba(26, 26, 26, 0.296875); -webkit-composition-fill-color: rgba(175, 192, 227, 0.230469); -webkit-composition-frame-color: rgba(77, 128, 180, 0.230469); ">"Mineralization of connective tissue with age is one of the many aspects of aging that are examples of "accumulation of eventually pathogenic extracellular material", an issue that attracts too little attention within the academic community. The accumulation of advanced glycation endproducts (AGEs) and of mineral deposits both result in increased stiffness of connective tissue, impair homeostasis and contribute to a broad range of age-related diseases. Through comprehensive bioinformatic analysis of the many molecular processes involved in mineralization, Zhavoronkov's team have identified possible molecular interventions. Additionally they propose that mineralization and AGEs work in concert and should be addressed concurrently. Anastasia Shyndyapina, the lead author on the paper, recently presented this work at the SENS6 conference in Cambridge.", <i><b>commented Dr. Aubrey de Grey</b></i>, <i><b>Chief Science Officer of SENS Research Foundation and International Adjunct Professor at the Moscow Institute of Physics and Technology (MIPT).</b></i></span></div>
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<span lang="EN-US">When you open a 70-year old patient on the
operating table and touch the aorta, the feeling may resemble touching an eggshell
or sand paper. It is stiffer than the heart of a young person and the key
reasons for this are the abundant calcium deposits in the connective tissue
that accumulate with age. Calcification is a significant cause of morbidity and
mortality because it is associated with atherosclerosis, chronic kidney disease
and osteoporosis.<span style="mso-spacerun: yes;"> </span></span></div>
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<span lang="EN-US">The many factors leading to mineralization
of the connective tissue include genetic and acquired diseases, inflammation,
reactive oxygen species, but the major problem is that it occurs spontaneously
during aging as calcium-containing molecules are trapped in the extracellular
matrix and develop into apatite over time. </span></div>
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<span lang="EN-US">Despite its relative significance, compared
to the many other areas of aging research, mineralization of the connective
tissue is rarely mentioned in scientific publications and few teams are working
on preventing or clearing out the extracellular aggregates. <span style="mso-spacerun: yes;"> </span>There are currently no drugs to treat vascular
calcification. </span></div>
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<span lang="EN-US">To address the problem, a multidisciplinary
team of physicians, bioinformatitians, biochemists and physicists performed a
comprehensive bioinformatics analysis of the many factors involved in
mineralization, identified key molecular targets and proposed a list of
possible drugs to address the issue. The next steps are <span style="mso-bidi-font-weight: bold;">clinical and experimental research that are supposed to make a great
contribution to the design of new treatments for vascular calcification and the
</span>regenerative medicine.</span></div>
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<b style="mso-bidi-font-weight: normal;"><span lang="EN-US">About
FOIRMYS</span></b></div>
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<span lang="EN-US">The First Open Institute for Regenerative
Medicine for Young Scientists (FOIRMYS) is a non-profit volunteer initiative
bringing together over a thousand enthusiast young scientists and physicians
interested in regenerative medicine. It was first organized by <a href="http://www.amazon.com/author/aging"><span style="color: windowtext; text-decoration: none; text-underline: none;">Alex Zhavoronkov</span></a>, PhD in
collaboration with Sergey Yakovenko, PhD, Sergey Roumiantsev, PhD and Oleg
Korzinov in Moscow with support from <a href="http://en.wikipedia.org/wiki/Anna_Chapman">Anna Chapman</a>. </span></div>
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<span lang="EN-US">FOIRMYS provides regular weekly lectures by
the top academic and industry thought leaders, investors and regulators. The
list of presenters includes Paolo Macchiarini (Karolinska Institute), Alexey
Aravin (Caltech), Charles Cantor (Boston U, ex-director of the Human Genome
Project), Augustinus Bader (Leipzig University), top managers from Beijing
Genomics Institute, Malaysian Genome Resource Center, Indigo Capital Partners
and many others. As part of the curriculum students participate in practicums
at “<a href="http://www.altravita.ru/">Altravita IVF</a>, <a href="http://www.fnkc.ru/">FRCCPH</a>, <a href="http://www.oncofinder.com/">FORCC</a>,
<a href="http://www.q-pharm.com/">Quantum Pharmaceuticals</a>, <a href="http://www.pharmcluster.ru/">Biopharmcluster “Northern”</a> and <a href="http://www.mipt.ru/">Moscow Institute of Physics and Technology</a>. </span></div><div class="MsoNormal"><span lang="EN-US"><br></span></div><div class="MsoNormal"><span lang="EN-US"><div class="separator" style="clear: both;"><a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEhizSqZeo8y6XptaaBOComkPg0AK_RZfjfkjxwlnbh_ZekFRfHDSrLdHDLG-Ho4BYHOqLPCK55nErRE_h-_fwR1BPhrBh2M9SjDe7cw5xLasZj8gLB14H1cUT0CYp7GCkz_c8MDbVq7-2ZG/s640/blogger-image-1695824799.jpg" imageanchor="1" style="margin-left: 1em; margin-right: 1em;"><img border="0" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEhizSqZeo8y6XptaaBOComkPg0AK_RZfjfkjxwlnbh_ZekFRfHDSrLdHDLG-Ho4BYHOqLPCK55nErRE_h-_fwR1BPhrBh2M9SjDe7cw5xLasZj8gLB14H1cUT0CYp7GCkz_c8MDbVq7-2ZG/s640/blogger-image-1695824799.jpg"></a></div><br></span></div><div class="MsoNormal"><span lang="EN-US"><br></span></div>
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<span lang="EN-US">Members work in small teams comprised of
scientists and physicians on ambitious outlier projects in aging and
regenerative medicine with topics ranging from mineralization of connective
tissue, HGPS and regulation of endometriosis to industry overviews and
healthcare economics. The projects are coordinated in a crowdsourced
environment and rely heavily on popular tools like Facebook, Dropbox and Google
Apps. <b><i>FOIRMYS developed a concept called “Personalized Medicine”</i></b>, where
projects are centered around the problems of a single patient, who provides
samples and helps coordinate the project. Members also learn how to promote
their work, create personal science blogs (including <b><i>Women in Science
initiative</i></b>) and engage in industry outreach. </span></div>
<div class="MsoNormal">
<span lang="EN-US">Participation in practical group projects
resulted in success stories including young scientists’ publications in
peer-reviewed journals, fellowships, participation in international
conferences, gainful employment of young scientists and international
collaborations.</span></div><div class="MsoNormal"><br></div>
<div class="MsoNormal">
<br></div>
<br></div>
Yana Aznaurovahttp://www.blogger.com/profile/00763932592404857719noreply@blogger.com2tag:blogger.com,1999:blog-1197119371590040835.post-77917437157134815332013-09-24T04:08:00.001-07:002013-09-24T15:14:33.787-07:00Overcoming bioinformatic program<div class="separator" style="clear: both;"><div class="separator" style="clear: both;">After the conference have finished we continued working at our project. </div><div class="separator" style="clear: both;">Our review "Regulation of endometriosis" includes<span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0); "> bioinformatic analysis of signaling pathways involved in the development of endometriosis. We found information about all the factors of adhesion, invasion and proliferation of endometrial cells and after that, we learned their signaling pathways.</span></div><div class="separator" style="clear: both;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0); ">When this part of work was done, we came to laboratory to unite all pathways on the overall map.</span></div><div class="separator" style="clear: both;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);"><br></span></div><div class="separator" style="clear: both;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">For that purpose we used software called MetaCore. It would be better to say we tried. </span><span style="background-color: rgba(255, 255, 255, 0); -webkit-text-size-adjust: auto; ">Because it turned out that working with such program for those who are used to dealing with real people (patients in our case) might be very difficult and unfamiliar challenge. At the first time we hadn't found a way to cooperate with this machine. </span></div><div class="separator" style="clear: both;"><br></div><div class="separator" style="clear: both;"><a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEhlhyphenhyphenxy6mzItNhlWa4I6WudhyAUokC1n0F2_-WpXkSs2hzHXyx5NbQXm8qoXPsAIEV5rwopOJhJgl-Ztk98O5XONV_FJ_YREv52OYMXSDIj_WxRwQ-fHNcPxIrJiRGLJyOV5jtop77pI_HN/s640/blogger-image-527852150.jpg" imageanchor="1" style="margin-left: 1em; margin-right: 1em;"><img border="0" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEhlhyphenhyphenxy6mzItNhlWa4I6WudhyAUokC1n0F2_-WpXkSs2hzHXyx5NbQXm8qoXPsAIEV5rwopOJhJgl-Ztk98O5XONV_FJ_YREv52OYMXSDIj_WxRwQ-fHNcPxIrJiRGLJyOV5jtop77pI_HN/s640/blogger-image-527852150.jpg"></a></div><br></div><div class="separator" style="clear: both;">But after 3 hours of work we finally succeeded to create our first network. <span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">And it was just the beginning! We found new ways of signaling pathways for certain factors, got some new articles on this issue and f</span><span style="-webkit-tap-highlight-color: rgba(26, 26, 26, 0.292969); -webkit-composition-fill-color: rgba(175, 192, 227, 0.230469); -webkit-composition-frame-color: rgba(77, 128, 180, 0.230469); -webkit-text-size-adjust: auto; ">urthermore, we merged different pathways and found </span><span style="-webkit-tap-highlight-color: rgba(26, 26, 26, 0.292969); -webkit-composition-fill-color: rgba(175, 192, 227, 0.230469); -webkit-composition-frame-color: rgba(77, 128, 180, 0.230469); -webkit-text-size-adjust: auto; ">points of their intersection. </span></div><div class="separator" style="clear: both;"><br></div><div class="separator" style="clear: both;"><a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEhHuWjLeOP713R-14DGVFBuIGcqVLNL7bWqTik1R0l6JziKZMJmZ24lqUz0_z9Yrsprvaw3J_J4wc15xr42fwyKBiB5Qa28UDLv-k0aWE_I21MDN3U9kKUOvB6FApryHXKATunhoH-bZswC/s640/blogger-image--884192436.jpg" imageanchor="1" style="margin-left: 1em; margin-right: 1em;"><img border="0" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEhHuWjLeOP713R-14DGVFBuIGcqVLNL7bWqTik1R0l6JziKZMJmZ24lqUz0_z9Yrsprvaw3J_J4wc15xr42fwyKBiB5Qa28UDLv-k0aWE_I21MDN3U9kKUOvB6FApryHXKATunhoH-bZswC/s640/blogger-image--884192436.jpg"></a></div><div class="separator" style="clear: both;"><br></div><div class="separator" style="clear: both;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">I think that it was an excellent result for the first attempt and certainly </span><span style="background-color: rgba(255, 255, 255, 0); -webkit-text-size-adjust: auto; ">an important experience for us!</span></div><div class="separator" style="clear: both;"><br></div><div class="separator" style="clear: both;"><br></div>Yana Aznaurovahttp://www.blogger.com/profile/00763932592404857719noreply@blogger.com0tag:blogger.com,1999:blog-1197119371590040835.post-59421174232240515102013-09-14T13:22:00.001-07:002013-09-20T16:06:11.745-07:00Friday, 6 of SeptemberIt was the last day of the SENS6 conference and w<span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">e were looking forward to today's lectures.</span><div><span style="background-color: rgba(255, 255, 255, 0); -webkit-text-size-adjust: auto; "><br></span></div><div><span style="background-color: rgba(255, 255, 255, 0); -webkit-text-size-adjust: auto; "><b><i>Josh Mitteldorf</i></b> gave a short lecture called <u>"How does the body know how old it is?"</u>. Josh </span><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">asked us to stand up and then he named four mechanisms of aging. Each of us had to sit down after that version </span><span style="background-color: rgba(255, 255, 255, 0); -webkit-text-size-adjust: auto; ">which he considers as more appropriate. Here they are:</span></div><div><span style="background-color: rgba(255, 255, 255, 0); -webkit-text-size-adjust: auto; ">1- antagonistic pleiotropy, </span></div><div><span style="-webkit-text-size-adjust: auto;">2- medawar hypothesis, </span></div><div><span style="-webkit-text-size-adjust: auto;">3- programmed aging,</span></div><div><span style="-webkit-text-size-adjust: auto;">4- everything wears out.</span></div><div><span style="-webkit-text-size-adjust: auto;"><br></span></div><div><span style="-webkit-text-size-adjust: auto;">I voted for third point, but most of people in auditorium sat after 4th one. After that, Josh was talking about hormesis, conserved genetic bases, two modes of programmed death in protists, breeding and an additive genetic variance for specific mortality. That how we know that aging is programmed. But if it's really programmed, we are to have a special clock for aging. Josh spoke about 4 possible clocks in our body: telomeres, hypothalamus, thymus and methylation.</span></div><div><span style="background-color: rgba(255, 255, 255, 0); -webkit-text-size-adjust: auto; "><br></span></div><div><span style="background-color: rgba(255, 255, 255, 0); -webkit-text-size-adjust: auto; "><div class="separator" style="clear: both;"><a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEgNgwNrIyAewV5bA_LsPB3bqgKgZLHIJMMpopp9UhjeXIJPP-4upPuzOT44OomxC6Uru9Yk-BpjrrsIlySOJC-KevNuHXK8wXDcVFuTsVQF0nSEIMW90CMvVXswBbbx5Z0VlhWg2AVJifBd/s640/blogger-image--1073144139.jpg" imageanchor="1" style="margin-left: 1em; margin-right: 1em;"><img border="0" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEgNgwNrIyAewV5bA_LsPB3bqgKgZLHIJMMpopp9UhjeXIJPP-4upPuzOT44OomxC6Uru9Yk-BpjrrsIlySOJC-KevNuHXK8wXDcVFuTsVQF0nSEIMW90CMvVXswBbbx5Z0VlhWg2AVJifBd/s640/blogger-image--1073144139.jpg"></a></div><br></span></div><div><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);"><br></span></div><div><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);"><b><i>Anastasia Shindyapina</i></b> from Lomonosov Moscow State University is one of the youngest speaker on conference. Her short talk about </span><span style="-webkit-tap-highlight-color: rgba(26, 26, 26, 0.292969); -webkit-composition-fill-color: rgba(175, 192, 227, 0.230469); -webkit-composition-frame-color: rgba(77, 128, 180, 0.230469); -webkit-text-size-adjust: auto; "><u>"Bioinformatic analysis of factors involved in age-related mineralization of soft tissues"</u> was very interesting and informative. </span></div><div><span style="-webkit-tap-highlight-color: rgba(26, 26, 26, 0.292969); -webkit-composition-fill-color: rgba(175, 192, 227, 0.230469); -webkit-composition-frame-color: rgba(77, 128, 180, 0.230469); -webkit-text-size-adjust: auto;">It's well known that age-related mineralization of the soft tissues is a passive process, but it's associate with a lot of disorders such as atherosclerosis and chronic kidney disease. At the same time there are many processes in our organism leading to calcification of structural cells and extracellular matrix. </span></div><div><span style="-webkit-tap-highlight-color: rgba(26, 26, 26, 0.292969); -webkit-composition-fill-color: rgba(175, 192, 227, 0.230469); -webkit-composition-frame-color: rgba(77, 128, 180, 0.230469); -webkit-text-size-adjust: auto;">Anastasia have demonstrated a bioinformatic network of the molecular pathways underlying calcification in atherosclerotic and chronic kidney disease patients and signaling pathways of collagen. Such analysis allowed young scientists team to propose new potential targets for calcification treatment. </span></div><div><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);"><br></span></div><div><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);"><div class="separator" style="clear: both;"><a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEgqfTgl9daVXks1RSZiP-1HnHXkSADYffXFsF9M5oCwLSVfYWnhDDE5yOKpA0CszGA3kS0llqu9j-9QbbpLEocyFh7OGmZ6vJus5K4HL6EuzXp8UUa-rUZnEljgxeqf6QjxE08H1g8Wsguv/s640/blogger-image-1518850677.jpg" imageanchor="1" style="margin-left: 1em; margin-right: 1em;"><img border="0" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEgqfTgl9daVXks1RSZiP-1HnHXkSADYffXFsF9M5oCwLSVfYWnhDDE5yOKpA0CszGA3kS0llqu9j-9QbbpLEocyFh7OGmZ6vJus5K4HL6EuzXp8UUa-rUZnEljgxeqf6QjxE08H1g8Wsguv/s640/blogger-image-1518850677.jpg"></a></div><br></span></div><div><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">We often talk about longevity from the point of health and quality of life. But the economy is an equally important part of this issue. If we want to live longer, we need money for research activities and for our future life. </span><b style="-webkit-text-size-adjust: auto; "><i>Alex Zhavoronkov</i></b><span style="background-color: rgba(255, 255, 255, 0); -webkit-text-size-adjust: auto; "> introduced us to his work called </span><span style="background-color: rgba(255, 255, 255, 0); -webkit-text-size-adjust: auto; ">"<u>New economic arguments for accelerating aging research"</u>, which was </span><span style="-webkit-tap-highlight-color: rgba(26, 26, 26, 0.296875); -webkit-composition-fill-color: rgba(175, 192, 227, 0.230469); -webkit-composition-frame-color: rgba(77, 128, 180, 0.230469); background-color: rgba(255, 255, 255, 0); -webkit-text-size-adjust: auto; ">made in collaboration with Maria Litovchenko (LabFairy.com) - young scientist from </span><span style="-webkit-tap-highlight-color: rgba(26, 26, 26, 0.296875); -webkit-composition-fill-color: rgba(175, 192, 227, 0.230469); -webkit-composition-frame-color: rgba(77, 128, 180, 0.230469); text-align: left; -webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0); ">Moscow Institute of Physics and Technology. </span><span style="background-color: rgba(255, 255, 255, 0); -webkit-text-size-adjust: auto; ">There were really great and difficult formulas of mortality rate, productivity and labor. For these formulas Alex used a new parameters such as </span></div><div><span style="background-color: rgba(255, 255, 255, 0); -webkit-text-size-adjust: auto; ">rejuvenation rate (RR),</span></div><div><span style="background-color: rgba(255, 255, 255, 0); -webkit-text-size-adjust: auto; ">non-rejuvenating rate of biotechnical progress (NRPR),</span></div><div><span style="background-color: rgba(255, 255, 255, 0); -webkit-text-size-adjust: auto; ">biomedical science and technology progress rate (BMTPR).</span></div><div><span style="background-color: rgba(255, 255, 255, 0); -webkit-text-size-adjust: auto; "><br></span></div><div><span style="background-color: rgba(255, 255, 255, 0); -webkit-text-size-adjust: auto; ">For better understanding we should divide our "old-life" in three parts: retirement age </span><span style="background-color: rgba(255, 255, 255, 0); -webkit-text-size-adjust: auto; ">(e.g. 65), healthy productive age (e.g. 75) and age of death (e.g. 85). So rejuvenation rate takes time between retirement age and healthy productive age and non-rejuvenating biomedical progress rate starts at the age of death.</span></div><div><span style="background-color: rgba(255, 255, 255, 0); -webkit-text-size-adjust: auto; ">The inference was that economy will grow when RR is greater than NRBPR and/or the retirement age in increasing faster than NRBPR - RR. After that, Alex gave a few recomendations, including accelerated aging research and refocused the research activities towards projects for life-extention.</span></div><div><span style="background-color: rgba(255, 255, 255, 0); -webkit-text-size-adjust: auto; "><br></span></div><div><span style="-webkit-tap-highlight-color: rgba(26, 26, 26, 0.296875); -webkit-composition-fill-color: rgba(175, 192, 227, 0.230469); -webkit-composition-frame-color: rgba(77, 128, 180, 0.230469); -webkit-text-size-adjust: auto; ">Copies of Alex's </span><span style="-webkit-tap-highlight-color: rgba(26, 26, 26, 0.292969); -webkit-composition-fill-color: rgba(175, 192, 227, 0.230469); -webkit-composition-frame-color: rgba(77, 128, 180, 0.230469); -webkit-text-size-adjust: auto; ">"The Ageless Generation" </span><span style="-webkit-tap-highlight-color: rgba(26, 26, 26, 0.292969); -webkit-composition-fill-color: rgba(175, 192, 227, 0.230469); -webkit-composition-frame-color: rgba(77, 128, 180, 0.230469); -webkit-text-size-adjust: auto; ">book about this issue was distributed to all SENS6 delegates.</span></div><div><span style="-webkit-tap-highlight-color: rgba(26, 26, 26, 0.292969); -webkit-composition-fill-color: rgba(175, 192, 227, 0.230469); -webkit-composition-frame-color: rgba(77, 128, 180, 0.230469); -webkit-text-size-adjust: auto; "><br></span></div><div><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);"><div class="separator" style="clear: both;"><a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEgio0j6Ukm_oISvLpnbkChLZmV3YRDMZARWWepCeNAqeYcy5BjHs9qCrKciqEoUHQZrDBjX4Q3QzAlJFnvlaXgcA89u3nZQeupFR7XIJh-q-ww0TatgDL1sC9Q6PT_lCoxk630ZKDs8cUWm/s640/blogger-image--538231479.jpg" imageanchor="1" style="margin-left: 1em; margin-right: 1em;"><img border="0" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEgio0j6Ukm_oISvLpnbkChLZmV3YRDMZARWWepCeNAqeYcy5BjHs9qCrKciqEoUHQZrDBjX4Q3QzAlJFnvlaXgcA89u3nZQeupFR7XIJh-q-ww0TatgDL1sC9Q6PT_lCoxk630ZKDs8cUWm/s640/blogger-image--538231479.jpg"></a></div><div class="separator" style="clear: both;"><br></div></span></div><div><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">In conclusion I would like to express my gratitude to <i><b>Aubrey de Grey</b></i> and all organizers, sponsors and speakers of SENS6 for the wonderful time we spent there. Hopefully, we will meet again on the next SENS-conference and discuss new outcomes of coping with aging.</span></div><div><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);"><div class="separator" style="clear: both;"><br></div><div class="separator" style="clear: both;"><div class="separator" style="clear: both;"><a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEjpY9ACJZ33RZ0A6ZBZqqQf6spfThYFXEAfKccRMCSpRO2Whz-F8qqQGxn7Ga_Jsv9LacZ8kQaLUm3JjZemEx1_6MFNqokXZYMIN6gRv6QUjpPhi6SFVMOcUuxi9T2bubnbmCoKNwvA8oEr/s640/blogger-image--2081547281.jpg" imageanchor="1" style="margin-left: 1em; margin-right: 1em;"><img border="0" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEjpY9ACJZ33RZ0A6ZBZqqQf6spfThYFXEAfKccRMCSpRO2Whz-F8qqQGxn7Ga_Jsv9LacZ8kQaLUm3JjZemEx1_6MFNqokXZYMIN6gRv6QUjpPhi6SFVMOcUuxi9T2bubnbmCoKNwvA8oEr/s640/blogger-image--2081547281.jpg"></a></div><br></div><br></span></div>Yana Aznaurovahttp://www.blogger.com/profile/00763932592404857719noreply@blogger.com0tag:blogger.com,1999:blog-1197119371590040835.post-50687030135081879362013-09-13T12:56:00.001-07:002013-09-16T07:23:08.471-07:00Thursday, 5 of September<div class="separator" style="clear: both;">Today we listened to the amazing and very cognitive lecture by <i><b>George Church</b></i> from Harvard Medical School. He was talking about new technologies and databases such as</div><div class="separator" style="clear: both;"><br></div><div class="separator" style="clear: both;">FISSEQ - <span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0); ">Fluorescent In Situ Sequencing;</span></div><div class="separator" style="clear: both;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">PGP - Personal Genome Project;</span></div><div class="separator" style="clear: both;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">CRISPR - </span><span style="background-color: rgba(255, 255, 255, 0); -webkit-text-size-adjust: auto; -webkit-tap-highlight-color: rgba(26, 26, 26, 0.292969); -webkit-composition-fill-color: rgba(175, 192, 227, 0.230469); -webkit-composition-frame-color: rgba(77, 128, 180, 0.230469); ">Genome Engineering Resources.</span></div><div class="separator" style="clear: both;"><br></div><div class="separator" style="clear: both;"><p style="margin-top: 0px; margin-bottom: 0px; "><font style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">The FISSEQ method includes sequencing-by-synthesis via few single-base extensions.</font></p></div><div class="separator" style="orphans: 2;clear: both; "><font color="#000000"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);"><span style="orphans: 4; ">CRISPR is a microbial nuclease which protect cell from invading phages and plasmids.</span></span></font></div><div class="separator" style="orphans: 2;clear: both; "><font color="#000000"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);"><span style="orphans: 4; "><br></span></span></font></div><div class="separator" style="orphans: 2;clear: both; "><img class="aligncenter wp-image-21" alt="crispr_processing_schematic" src="http://www.genome-engineering.org/crispr/wp-content/uploads/2013/01/crispr_processing1.jpg" width="480" height="382" style="orphans: 2; text-align: -webkit-auto; margin: 0px auto; padding: 0px; border: 0px; outline: 0px; vertical-align: middle; height: auto; display: block; max-width: 100%; "></div><div class="separator" style="clear: both;"><span style="-webkit-tap-highlight-color: rgba(26, 26, 26, 0.292969); -webkit-composition-fill-color: rgba(175, 192, 227, 0.230469); -webkit-composition-frame-color: rgba(77, 128, 180, 0.230469); -webkit-text-size-adjust: auto; "><br></span></div><div class="separator" style="clear: both;"><span style="-webkit-tap-highlight-color: rgba(26, 26, 26, 0.292969); -webkit-composition-fill-color: rgba(175, 192, 227, 0.230469); -webkit-composition-frame-color: rgba(77, 128, 180, 0.230469); -webkit-text-size-adjust: auto; ">It's a great idea to create a large database like Personal Genome Project and share data with other scientists from all over the world. This data can be used for sequencing transcriptomes, immunomes, microbiomes so it's very important for scientific progress.</span></div><div class="separator" style="clear: both;"><br></div><div class="separator" style="clear: both;"><a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEi1H27RKzKJCj-GeMcphyphenhyphenuipGhyphenhyphenPQC4hgS75Bq9chjHfje3FiRi8ojWLh2ehK4958FHCkXBAf_5TFsnxCD2JNgQ7pwO6sIqUxe0Dqw7Tal6ngMwEO4fF2tnHGlNktiCQh8YQxToc2WT39LD/s640/blogger-image-1764955325.jpg" imageanchor="1" style="margin-left: 1em; margin-right: 1em;"><img border="0" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEi1H27RKzKJCj-GeMcphyphenhyphenuipGhyphenhyphenPQC4hgS75Bq9chjHfje3FiRi8ojWLh2ehK4958FHCkXBAf_5TFsnxCD2JNgQ7pwO6sIqUxe0Dqw7Tal6ngMwEO4fF2tnHGlNktiCQh8YQxToc2WT39LD/s640/blogger-image-1764955325.jpg"></a></div><div class="separator" style="clear: both;"><br></div><div class="separator" style="clear: both;"><b style="font-style: italic; ">Rafal Smigrodzki </b><span style="-webkit-text-size-adjust: auto;">from Gencia Corporation gave a short lecture in session called "Mitochondria". Mitochondrial disfunction in aging found expression in supression of oxidative phosphorylation and an increasing of glycolysis. It was noted that stimulation of mitochondrial activity can supresses neoplastic growth, improves cellular function and aged animal cognition. It's going to take an important place in aging therapies.</span></div><div class="separator" style="clear: both;"><br></div><div class="separator" style="clear: both;"><i><b>Dirk Hockemeyer</b></i> from University of California at Berkeley told us about molecular mechanisms of telomerase regulation in genetically defined human stem cell models. It's well known that disfunction of telomerases can lead to aging and tumorigenesis. Dick and collegues used a site-specific nucleases to genetically engineer human pluripotent stem cells and studied the two main regulatory processes of human telomerase function in a stem cells system( transcriptional regulation and the recruitment of the telomerase holoenzyme to telomers).</div><div class="separator" style="clear: both;"><br></div><div class="separator" style="clear: both;"><br></div><div class="separator" style="clear: both;"><br></div><div class="separator" style="clear: both;"><br></div><div class="separator" style="clear: both;"><span style="-webkit-tap-highlight-color: rgba(26, 26, 26, 0.292969); -webkit-composition-fill-color: rgba(175, 192, 227, 0.230469); -webkit-composition-frame-color: rgba(77, 128, 180, 0.230469); -webkit-text-size-adjust: auto; "><br></span></div><div class="separator" style="clear: both;"><span style="-webkit-tap-highlight-color: rgba(26, 26, 26, 0.292969); -webkit-composition-fill-color: rgba(175, 192, 227, 0.230469); -webkit-composition-frame-color: rgba(77, 128, 180, 0.230469); -webkit-text-size-adjust: auto; "><br></span></div><div class="separator" style="clear: both;"><div class="separator" style="clear: both;"><br></div><br></div>Yana Aznaurovahttp://www.blogger.com/profile/00763932592404857719noreply@blogger.com2tag:blogger.com,1999:blog-1197119371590040835.post-64740441007606194892013-09-13T12:49:00.001-07:002013-09-14T12:38:35.743-07:00Wednesday, 4 of September<div>This day we spent at five sessions: </div>
<div><span style="background-color: rgba(255, 255, 255, 0.0078125);">• T</span>elomers and cancer,</div>
<div><span style="background-color: rgba(255, 255, 255, 0.0078125);">• </span>Combating persistent viruses, </div>
<div><span style="background-color: rgba(255, 255, 255, 0.0078125);">• </span>Cell senescence and anergy,</div>
<div><span style="background-color: rgba(255, 255, 255, 0.0078125);">•</span> Disruptive medicine, </div>
<div><span style="background-color: rgba(255, 255, 255, 0.0078125);">• </span>Cardiovascular aging.</div>
<div><br></div>
<div><b><i>Rigdon Lentz</i></b> talk was called <i>"Apheresis of TNF and IL-2 disrupts tumor immunoevasion"</i>. TNF and IL-2 are known to ba pro-inflammatory cytokines produced by activated mononuclear white blood cells. These cells link up tumor cells via specific receptors. Connecting of cytokines (TNF and IL-2) and these receptors leads to cell death by apoptosis and oxidative stress. At the same time tumor cells can produce such soluble receptors for TNF and IL-2 as <u>sTNF-R1, sTNF-R2 and sIL-2</u> and this fact is most likely to be a main mechanism by which tumor cells could block and avoid attack of immune system. Rigdon proposed the extracorporeal removal of these inhibitors via apheresis device. I was impressed by outcome of this study: metastatic patients who receive multiple treatment cycles and have clinical symptoms of tumor inflammation further show <u>X-ray and CT signs of tumor necrosis and reduction</u>!</div><div><br></div><div><i><b>Todd Rider</b></i> was talking about new approach in antiviral therapeutics. <i><u>Double-stranded RNA (dsRNA) Activated Caspase Oligomerizer (DRACO) </u></i>could selectively induce provoke apoptosis in cells containing viral dsRNA without killing uninfected cells. Furthermore, it was demonstrated in mice that DRACO quickly penetrate into all organs, persist for over 24 hours and are nontoxic. DRACO was demonstrated as <u>very effective against 15 different viruses</u>, including H1N1 influenza, Tacaribe arenavirus, Amapari <span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">arenavirus and Guama</span> bunyavirus.</div><div><br></div><div><div class="separator" style="clear: both;"><a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEiXVGgZnqA1MD1FqIQd-3xhrbyI1CW1KLT-BsvcI1_5qMmE05Gx9I77STiDwWli8WqI17EpMdj0lXthvxmXUIRL4PcM_bbe6YM4K0ReQ-aoToCtSta2hjnbKMxkS4ISa1v8yinL7Ruk3cwV/s640/blogger-image--718019756.jpg" imageanchor="1" style="margin-left: 1em; margin-right: 1em;"><img border="0" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEiXVGgZnqA1MD1FqIQd-3xhrbyI1CW1KLT-BsvcI1_5qMmE05Gx9I77STiDwWli8WqI17EpMdj0lXthvxmXUIRL4PcM_bbe6YM4K0ReQ-aoToCtSta2hjnbKMxkS4ISa1v8yinL7Ruk3cwV/s640/blogger-image--718019756.jpg"></a></div><div class="separator" style="clear: both;"><br></div><div class="separator" style="clear: both;">We met very interesting poster at the poster-session and got to know one of the authors of it - <i><b>Stuart Calimport</b></i>. <u>The Human Memome Project</u> was made with aim to identify socio-cultural markers of longevity. Data was collected from over 300 participants, 25 countries, in an 18-70-age range. Authors used statistical analysis and computational modeling techniques to build optimal sets of behaviors, interests that correlate with longevity. </div><br></div><div><div class="separator" style="clear: both;"><a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEjNbSQdJNa_SueZQYlfNyGLLqwM3ylAU3gKDj18EhPy5w2P08-IheyOla_4PVWgjXK9ujXMKY0ylbuVSP5Yb8rzOtZrsh0II2V3GC_-xXUZoaL8wMfHC1G9E2xYim0O7cW6YKYU_hESeCEG/s640/blogger-image-1138993337.jpg" imageanchor="1" style="margin-left: 1em; margin-right: 1em;"><img border="0" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEjNbSQdJNa_SueZQYlfNyGLLqwM3ylAU3gKDj18EhPy5w2P08-IheyOla_4PVWgjXK9ujXMKY0ylbuVSP5Yb8rzOtZrsh0II2V3GC_-xXUZoaL8wMfHC1G9E2xYim0O7cW6YKYU_hESeCEG/s640/blogger-image-1138993337.jpg"></a></div><br></div><div><br></div><div><br></div>
<div></div>Yana Aznaurovahttp://www.blogger.com/profile/00763932592404857719noreply@blogger.com0tag:blogger.com,1999:blog-1197119371590040835.post-59144675220835478682013-09-13T05:02:00.001-07:002013-09-20T15:51:01.805-07:00Tuesday, 3 of September. First day of SENS6 or does eating less mean
living longer<div><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">Our team led by <i><b>Alex Zhavoronkov</b></i> arrived in Cambridge. Old Colleges among the wonderful scenery - </span><span style="-webkit-tap-highlight-color: rgba(26, 26, 26, 0.292969); -webkit-composition-fill-color: rgba(175, 192, 227, 0.230469); -webkit-composition-frame-color: rgba(77, 128, 180, 0.230469); -webkit-text-size-adjust: auto; ">you can not come up with a place for the conference better than it. </span></div><div><span style="-webkit-tap-highlight-color: rgba(26, 26, 26, 0.292969); -webkit-composition-fill-color: rgba(175, 192, 227, 0.230469); -webkit-composition-frame-color: rgba(77, 128, 180, 0.230469); -webkit-text-size-adjust: auto; ">We had a t</span><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">ight schedule and here I'll write about the most interesting lectures and meetings of each day.</span></div><div><br></div><div><div class="separator" style="clear: both;"><a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEjJYtEZ54Q2A7HTE-N2pEhTMi6hpjviAF_nKg0eCl2zYPdb_Djz7b6p8P1k5qlBhrw_FkY3Bk86i3SOhjXJyuyduWS8mhrn_NUKMcATOjSHtgZtz4zN2xe_Jx8yvfnEoYJbkRZyPN5TAk7H/s640/blogger-image--518966590.jpg" imageanchor="1" style="margin-left: 1em; margin-right: 1em;"><img border="0" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEjJYtEZ54Q2A7HTE-N2pEhTMi6hpjviAF_nKg0eCl2zYPdb_Djz7b6p8P1k5qlBhrw_FkY3Bk86i3SOhjXJyuyduWS8mhrn_NUKMcATOjSHtgZtz4zN2xe_Jx8yvfnEoYJbkRZyPN5TAk7H/s640/blogger-image--518966590.jpg"></a></div><div class="separator" style="clear: both;"><br></div><i>Queen's College, Cambridge</i></div><div><br></div><div><div class="separator" style="clear: both;"><a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEgbBUQYroJ40DTB8i7FwrCNDZfIDhNBYRLHDWG8QjNNn2IFb5HLOCuk-D_PYF0XUqD_Xo0jOgvq4m8p_KPaO6uKHxsSz9hQXsKlQFTKD4L9PbkC4RKMijNoR_9atQ-U_qIfSSKm8kUZwzhl/s640/blogger-image-1512094289.jpg" imageanchor="1" style="margin-left: 1em; margin-right: 1em;"><img border="0" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEgbBUQYroJ40DTB8i7FwrCNDZfIDhNBYRLHDWG8QjNNn2IFb5HLOCuk-D_PYF0XUqD_Xo0jOgvq4m8p_KPaO6uKHxsSz9hQXsKlQFTKD4L9PbkC4RKMijNoR_9atQ-U_qIfSSKm8kUZwzhl/s640/blogger-image-1512094289.jpg"></a></div><br></div><div><br></div><div><b>First session</b> was initiate into <b>calorie restriction in primates</b> and possibility of this strategy in human. </div><div><br>Caloric restriction is a dietary regimen of reduced calorie intake without malnutrition which has been shown to hold aging up, according to 20 years of data.<br><br><b><i>Rozalyn Anderson</i></b> from University of Wisconsin told us that factors involved in regulation of metabolism are likely to be important in the mechanism of lifespan extension. Aging is associated with slowing down of energy metabolism and decreased expression of mitochondrial genes. These suppositions baking a model where reprogramming of energy metabolism have a main role in the mechanisms of caloric restriction.<br><br>After that, Rozalyn Anderson and <i><b>Donald Ingram</b></i> from Pennington Biomedical Research Center were talking about different survival outcomes of two monkey caloric restriction studies: <i>UW (University of Wisconsin) and NIA (National Institute on Aging)</i>. The reasons discussed there include genetic origin of the study hogort, feeding regimens, dietary composition and protocols for animal husbandry.</div><div><br></div><div><div class="separator" style="clear: both;"><a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEjDi-6E_9QA3fCCdvWjTwcAtkpjIZEtvPkS10r-4Luzlavb9R8wKNEkAL8xWEIkxiZ4_MV07NaVQeKhq0-mjMoeeunu01CDioALm2urzVsmhSq_cOAfvYr8ao3NXG2170Fb1XnhoYosozlL/s640/blogger-image--1867483781.jpg" imageanchor="1" style="margin-left: 1em; margin-right: 1em;"><img border="0" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEjDi-6E_9QA3fCCdvWjTwcAtkpjIZEtvPkS10r-4Luzlavb9R8wKNEkAL8xWEIkxiZ4_MV07NaVQeKhq0-mjMoeeunu01CDioALm2urzVsmhSq_cOAfvYr8ao3NXG2170Fb1XnhoYosozlL/s640/blogger-image--1867483781.jpg"></a></div><div class="separator" style="clear: both;"><div><a href="http://www.primate.wisc.edu/" x-apple-data-detectors="true" x-apple-data-detectors-type="link" x-apple-data-detectors-result="1"></a><div><a href="http://www.primate.wisc.edu/" x-apple-data-detectors="true" x-apple-data-detectors-type="link" x-apple-data-detectors-result="1"></a><a href="http://www.primate.wisc.edu/" x-apple-data-detectors="true" x-apple-data-detectors-type="link" x-apple-data-detectors-result="1">http://www.primate.wisc.edu/</a></div></div><div><br></div><div>Photos of monkeys who participated in that studies have been demonstrated. Undoubtedly, calorie restriction provided a nice coat, elastic skin and more energetic behaviour. But in my opinion, the monkey that was kept on a diet looked a little bit nervous. I think that we are to look after their emotional status too because <b><i>would they like to live longer in case they don't enjoy it?</i></b></div><div></div></div><br></div><div><div class="separator" style="clear: both;"><a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEj2xCBOU2P52AMvQf2VUopibeDXqgDpgvTYgNjjsEo6G65yZ6Z0saGf0J-xsIRdcCNXGroZnNBlhhrxW-f_dk90FmSvuurg4l4DUZ11ht26ejp7jirAAyQd05fzWLnh-UzOlZICQR2iHUM4/s640/blogger-image-1054940640.jpg" imageanchor="1" style="margin-left: 1em; margin-right: 1em;"><img border="0" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEj2xCBOU2P52AMvQf2VUopibeDXqgDpgvTYgNjjsEo6G65yZ6Z0saGf0J-xsIRdcCNXGroZnNBlhhrxW-f_dk90FmSvuurg4l4DUZ11ht26ejp7jirAAyQd05fzWLnh-UzOlZICQR2iHUM4/s640/blogger-image-1054940640.jpg"></a></div><div class="separator" style="clear: both;"><a href="http://pavlovsape.wordpress.com/2010/06/05/paul-mcglothin-how-to-survive-on-a-low-calorie-diet/" x-apple-data-detectors="true" x-apple-data-detectors-type="link" x-apple-data-detectors-result="2"></a><div><a href="http://pavlovsape.wordpress.com/2010/06/05/paul-mcglothin-how-to-survive-on-a-low-calorie-diet/" x-apple-data-detectors="true" x-apple-data-detectors-type="link" x-apple-data-detectors-result="2"></a><a href="http://pavlovsape.wordpress.com/2010/06/05/paul-mcglothin-how-to-survive-on-a-low-calorie-diet/" x-apple-data-detectors="true" x-apple-data-detectors-type="link" x-apple-data-detectors-result="2">http://pavlovsape.wordpress.com/2010/06/05/paul-mcglothin-how-to-survive-on-a-low-calorie-diet/</a></div></div><br></div><div><br></div>Yana Aznaurovahttp://www.blogger.com/profile/00763932592404857719noreply@blogger.com0tag:blogger.com,1999:blog-1197119371590040835.post-10060247903948437192013-08-25T03:49:00.000-07:002013-08-25T04:01:06.455-07:00SENS6<div dir="ltr" style="text-align: left;" trbidi="on">
<span style="background-color: rgba(255, 255, 255, 0);"><b>SENS6</b> <b>(September 3-7 in Cambridge UK)</b> is perhaps the most comprehensive, complete and diverse conference on Aging Research worldwide.<br>It caters to scientists, policy makers, students, journalists, wealthy individuals and general public interested in aging research. There are many talks are very technical and require in-depth knowledge of the underlying subject; however, many talks will provide general introduction into many areas of aging research. </span><br>
<span style="background-color: rgba(255, 255, 255, 0);"><br>In the case that you are a <b>young scientist</b> ready to step on the path of helping overcome humanity's greatest challenge, or thinking about how to contribute or get involved, this conference is for you! Many of us started this journey at SENS. It is<span class="text_exposed_show" style="display: inline;"> worth every penny and you will remember it for the rest of your life.</span></span><br>
<span style="background-color: rgba(255, 255, 255, 0);"><span class="text_exposed_show" style="display: inline;"><br></span></span><div class="separator" style="clear: both;"><a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEgh4kgXvIoJdacq6fvsHYXR1b-mAnSKLA8d7JwEK-iKhdGQlJethuWaQYEvezBXP5HYr7MtwjMf7qepG42FxSQGLa51yb03NPnTdFchtMm2k1iSFGrNdzS9pufjEdVjixN8VwRTpoTbVlHD/s640/blogger-image-1617879675.jpg" imageanchor="1" style="margin-left: 1em; margin-right: 1em;"><img border="0" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEgh4kgXvIoJdacq6fvsHYXR1b-mAnSKLA8d7JwEK-iKhdGQlJethuWaQYEvezBXP5HYr7MtwjMf7qepG42FxSQGLa51yb03NPnTdFchtMm2k1iSFGrNdzS9pufjEdVjixN8VwRTpoTbVlHD/s640/blogger-image-1617879675.jpg"></a></div><br>
<span style="-webkit-composition-fill-color: rgba(175, 192, 227, 0.230469); -webkit-composition-frame-color: rgba(77, 128, 180, 0.230469); -webkit-tap-highlight-color: rgba(26, 26, 26, 0.296875); font-family: '.HelveticaNeueUI'; font-size: 15px; line-height: 19px; text-align: -webkit-auto; white-space: nowrap;">http://www.sens.org/outreach/conferences/sens6</span><br>
<br>
<span style="background-color: rgba(255, 255, 255, 0);"><span class="text_exposed_show" style="display: inline;"><br><b><i>The registration fee includes</i></b> accommodation at one of the most historic and respectable colleges at Cambridge and the SENS Foundation is heavily subsidizing the conference. They are not making money on you. This is your chance to enjoy the exhilarating Cambridge atmosphere while interacting with the world's top academic and industry luminaries from all over the world. Some of these conversations will transpire over locally-brewed alcohol and end up in life-long (possibly extraordinarily long life) friendships and collaborations.</span></span><br>
<span style="background-color: rgba(255, 255, 255, 0);"><span class="text_exposed_show" style="display: inline;"><br><i><b>We will be giving away 300 "Ageless Generation" books to the conference delegates for free</b></i> (<a href="http://www.facebook.com/l.php?u=http%3A%2F%2Fus.macmillan.com%2Ftheagelessgeneration%2F&h=yAQGKrUy1AQFb5tYcGIW3XO0Wqf9TciQvqanKCXoyDJlWfg&s=1" rel="nofollow nofollow" style="cursor: pointer; text-decoration: none;" target="_blank">http://us.macmillan.com/<wbr><span class="word_break" style="display: inline-block;"></span>theagelessgeneration/</a>).<br><br>There is <u>less than 10 days left</u> and the conference is likely to sell out, since the number of rooms at Queen's College is limited.<br><b>Register today and you will never regret this life-changing decision!</b></span></span></div>
Yana Aznaurovahttp://www.blogger.com/profile/00763932592404857719noreply@blogger.com1tag:blogger.com,1999:blog-1197119371590040835.post-75551367759368755702013-07-05T06:27:00.000-07:002013-07-05T07:22:23.891-07:00What I'm going to talk about...I would like to tell you about my current scientific work. Our team is studying an
<b><i>endometriosis </i></b>disease. Nowadays endometriosis is considered as an <i>incurable illness</i>.
It has a great variety of etiology and pathogenesis theories. Doctors and
scientists still cannot say surely what is the reason of appearing endometriosis in women
of <i>reproductive age</i>. Within the framework of our project “<b>The regulation of endometriosis</b>”
we are studying endometriosis in concrete patient, carrying out a full diagnostics and
hope to find the right target for the selection of therapy.<br />
<br />
<b>Personal approach</b> is that we
want to attract women with endometriosis. Each case is individual and can have different
symptoms and passing. It is necessary not only to examine each patient from the point of
settled guidelines but also to correct them on depends of particular qualities of passing of
endometriosis <i>in each woman.</i><br />
<i><br /></i>
<br />
<div class="separator" style="clear: both; text-align: center;">
<a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEhrhFL-LR51g4LJRKjEt0TClWAUWEXBECVpimEiz5_BE-Mom6sYqMRBNfVZ6Z-R4iuKKAs3M8nAqIKtGYyoRT6iOeD965wjSUYGvxW5h-DgOmZDHopBZouT-jify1RpxtwkHH5Cw6R_KnZu/s1600/Yana_1.jpg" imageanchor="1" style="margin-left: 1em; margin-right: 1em;"><img border="0" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEhrhFL-LR51g4LJRKjEt0TClWAUWEXBECVpimEiz5_BE-Mom6sYqMRBNfVZ6Z-R4iuKKAs3M8nAqIKtGYyoRT6iOeD965wjSUYGvxW5h-DgOmZDHopBZouT-jify1RpxtwkHH5Cw6R_KnZu/s1600/Yana_1.jpg" height="212" width="320" /></a></div>
<i><br /></i>Yana Aznaurovahttp://www.blogger.com/profile/00763932592404857719noreply@blogger.com0озеро Байкал, Россия53.5657849 108.2094861000000548.747051899999995 97.882337600000056 58.3845179 118.53663460000004tag:blogger.com,1999:blog-1197119371590040835.post-53618759903035040442013-05-24T10:55:00.002-07:002013-07-12T15:40:13.926-07:00Hello World <div dir="ltr" style="text-align: left;" trbidi="on">
This blog is now live!<br />
<br />
<div class="MsoNormal">
<span lang="EN-US" style="mso-ansi-language: EN-US;">My name is
Yana, I am 20.</span></div>
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<span lang="EN-US" style="mso-ansi-language: EN-US;">I came from the family of doctors and since my
childhood I have been surrounded by <i>a wonderful atmosphere</i>. Since that time I
have seen how the doctor's decision, his thoughts then realized in actions,
save people's lives and change the world around patients. </span></div>
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<a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEhaI7Rh-FZG9B-yBpYHuAGzhdhvmQ_7DMA8Jm9T9afout446-yOAj7K6A9zGGxqKsYSvnGssVlqEbsFcQPs4PND2b6Fb6YoO7uhg6l-R3AHeihay5aikxWu4fo08SGlrtiHlpmOExPx6Nuy/s1600/%D0%98%D0%B7%D0%BE%D0%B1%D1%80%D0%B0%D0%B6%D0%B5%D0%BD%D0%B8%D0%B5+192.jpg" imageanchor="1" style="margin-left: 1em; margin-right: 1em;"><img border="0" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEhaI7Rh-FZG9B-yBpYHuAGzhdhvmQ_7DMA8Jm9T9afout446-yOAj7K6A9zGGxqKsYSvnGssVlqEbsFcQPs4PND2b6Fb6YoO7uhg6l-R3AHeihay5aikxWu4fo08SGlrtiHlpmOExPx6Nuy/s1600/%D0%98%D0%B7%D0%BE%D0%B1%D1%80%D0%B0%D0%B6%D0%B5%D0%BD%D0%B8%D0%B5+192.jpg" height="213" width="320" /></a><br />
<br />
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<span lang="EN-US" style="mso-ansi-language: EN-US;">Now I'm a 5
year student of the faculty "Medicine of the future" in the I.M.
Sechenov First Moscow State Medical University and want to become
<i>obstetrician-gynecologist.</i> For me it's an inexpressible feeling when I see a
pregnant woman and understand, that after a certain time a great happiness will
come in her family, which will completely change her life. But for the definite
reasons many women are deprived of their happiness to hear the words “you will
have a kid”. So I am particularly interested in diseases that lead to
infertility.</span></div>
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<span lang="EN-US" style="mso-ansi-language: EN-US;"><br /></span></div>
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<span lang="EN-US" style="mso-ansi-language: EN-US;">Except
medicine I’m fond of dancing since childhood. I finished the ballet school,
danced in the troupe of the Tsaritsyn opera and I was a leading dancer of the
folk dance ensemble.</span><span lang="EN-US" style="mso-ansi-language: EN-US;"> </span></div>
<span lang="EN-US" style="mso-ansi-language: EN-US;"><br /></span>
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<span lang="EN-US" style="mso-ansi-language: EN-US;">I want to
become something more than a clinician. <i>New ideas, new diagnostic methods and
treatment approaches</i> that’s what interests me. I am keen on learning and
discovering the different sides of science and medicine.</span>
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Yana Aznaurovahttp://www.blogger.com/profile/00763932592404857719noreply@blogger.com0